Fri Apr 22 2022

65 articles - From Saturday Apr 16 2022 to Friday Apr 22 2022

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Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews


Original articles

RCT, clinical trials, retrospective studies, etc…

Ann Intern Med

Adverse Events Associated With Coprescription of Phosphodiesterase Type 5 Inhibitors and Oral Organic Nitrates in Male Patients With Ischemic Heart Disease : A Case-Crossover Study.

From 2000 to 2018, the use of PDE5 inhibitors increased 20-fold among Danish patients with IHD who were taking nitrates. A statistically significant association between concomitant use of these medications and cardiovascular adverse events could not be identified. Primary funding source Ib Mogens Kristiansens Almene Fond and Helsefonden.

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Mortality and Morbidity in Mild Primary Hyperparathyroidism: Results From a 10-Year Prospective Randomized Controlled Trial of Parathyroidectomy Versus Observation.

Parathyroidectomy does not appear to reduce morbidity or mortality in mild PHPT. Thus, no evidence of adverse effects of observation was seen for at least a decade with respect to mortality, fractures, cancer, cardiovascular and cerebrovascular events, or renal morbidities. Primary funding source Swedish government, Norwegian Research Council, and South-Eastern Norway Regional Health Authority.

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Lancet

Efficacy, safety, and immunogenicity of an inactivated, adjuvanted enterovirus 71 vaccine in infants and children: a multiregion, double-blind, randomised, placebo-controlled, phase 3 trial.

Almost al reported solicited adverse events were mild and self-limited. Interpretation EV71vac is safe, well-tolerated, and highly effective in preventing EV71 associated diseases in children aged 2-71 months. Funding Medigen Vaccine Biologics and A+ Industrial Innovative R&D Program of the Ministry of Economic Affairs, Taiwan.

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N Engl J Med

Calorie Restriction with or without Time-Restricted Eating in Weight Loss.

Among patients with obesity, a regimen of time-restricted eating was not more beneficial with regard to reduction in body weight, body fat, or metabolic risk factors than daily calorie restriction. (Funded by the National Key Research and Development Project [No. 2018YFA0800404] and others; ClinicalTrials.gov number, NCT03745612.).

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Intramuscular AZD7442 (Tixagevimab-Cilgavimab) for Prevention of Covid-19.

A single dose of AZD7442 had efficacy for the prevention of Covid-19, without evident safety concerns. (Funded by AstraZeneca and the U.S. government; PROVENT ClinicalTrials.gov number, NCT04625725.).

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Ivosidenib and Azacitidine in IDH1-Mutated Acute Myeloid Leukemia.

Ivosidenib and azacitidine showed significant clinical benefit as compared with placebo and azacitidine in this difficult-to-treat population. Febrile neutropenia and infections were less frequent in the ivosidenib-and-azacitidine group than in the placebo-and-azacitidine group, whereas neutropenia and bleeding were more frequent in the ivosidenib-and-azacitidine group. (Funded by Agios Pharmaceuticals and Servier Pharmaceuticals; AGILE ClinicalTrials.gov number, NCT03173248.).

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Ann Intern Med

Direct-to-Consumer Generic Drugs: A Maverick Approach or Another Exposure of Market Failures?

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The Challenge of Genetic Variants of Uncertain Clinical Significance : A Narrative Review.

Additional strategies can help mitigate the potential harms of VUSs, including testing protocols that limit identification or reporting of VUSs, subclassification of VUSs according to the likelihood of pathogenicity, routine family-based evaluation of variants, and enhanced counseling efforts. All involve tradeoffs, and the appropriate balance of measures is likely to vary for different test uses and clinical settings. Cross-specialty deliberation and public input could contribute to systematic and broadly supported policies for managing VUSs.

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Lancet

Cancer care: beyond survival.

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Improved models of care for cancer survivors.

Improved models should shift from a predominant focus on detection of cancer recurrence and seek to improve the quality of life, functional outcomes, experience, and survival of survivors of cancer, reduce the risk of recurrence and new cancers, improve the management of comorbidities, and reduce costs to patients and payers. This Series paper focuses primarily on high-income countries, where most data have been derived. However, future research should consider the applicability of these models in a wider range of health-care settings and for a wider range of cancers.

Pubmed   Journal   ReadQx   PMC

Long-term care for people treated for cancer during childhood and adolescence.

Survivors of childhood and adolescent cancer are at risk for a range of late-occuring side-effects from treatment, including cardiac, endocrine, pulmonary, fertility, renal, psychological, cognitive, and socio-developmental impairments. Care coordination and transition to adult care are substantial challenges, but can be empowering for survivors and improve outcomes, and could be facilitated by clear, effective communication and support for self-management. Resources for adult clinical care teams and primary care providers include late-effects surveillance guidelines and web-based support services.

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Management of common clinical problems experienced by survivors of cancer.

Review of lifestyle factors including smoking, obesity, and alcohol is necessary to reduce the risk of recurrence and second cancers. Exercise can improve quality of life and might improve cancer survival; it can also contribute to the management of fatigue, pain, metabolic syndrome, osteoporosis, and cognitive impairment. Using a supportive care screening tool, such as the Distress Thermometer, can identify specific areas of concern and help prioritise areas to cover in a consultation.

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Offline: Finding hope under the Emperor's New Clothes.

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N Engl J Med

Audio Interview: The Effects of Covid-19 on Children.

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Breaking the Skin Color Barriers for Asthma Medications - It's Not Black, Brown, or White.

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Calorie and Time Restriction in Weight Loss.

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Increasing Incidence of Early-Onset Colorectal Cancer.

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Letters&Replies

Letters to the editors and authors’ replies

Lancet

Fetal dysanatrophy-a new discipline?

Pubmed   Journal   ReadQx 

Understanding the social determinants of health - Authors' reply.

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Understanding the social determinants of health.

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N Engl J Med

Cardiovascular Events with Finerenone in CKD and Diabetes.

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Cardiovascular Events with Finerenone in CKD and Diabetes.

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Cardiovascular Events with Finerenone in CKD and Diabetes.

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Cardiovascular Events with Finerenone in CKD and Diabetes. Reply.

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Current Causes of Death in Children and Adolescents in the United States.

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Determination of Brain Death.

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Determination of Brain Death. Reply.

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Intrinsic Severity of the SARS-CoV-2 Omicron Variant.

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Intrinsic Severity of the SARS-CoV-2 Omicron Variant. Reply.

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Others

all remaining publications eg case reports, images of the month, etc…

Ann Intern Med

A Poem of Rivers and Trees.

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A Triolet for Newly Hatched Docs.

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Annals for Educators - April 2022.

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Annals for Hospitalists - April 2022.

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Comparison of a Hemostatic Powder and Standard Treatment in the Control of Active Bleeding From Upper Nonvariceal Lesions.

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Comparison of a Hemostatic Powder and Standard Treatment in the Control of Active Bleeding From Upper Nonvariceal Lesions.

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Day One Med School Class Reunion.

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End the Ban: A Military Doctor's Perspective.

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Night Light.

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Nonoperative Management of Mild Primary Hyperparathyroidism: A Reasonable, Evidence-Based Option.

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Risk for Recurrent Venous Thromboembolism in Patients With Subsegmental Pulmonary Embolism Managed Without Anticoagulation.

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Risk for Recurrent Venous Thromboembolism in Patients With Subsegmental Pulmonary Embolism Managed Without Anticoagulation.

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Summary for Patients: Mortality and Morbidity in Mild Primary Hyperparathyroidism.

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Summary for Patients: Risk for Unwanted Outcomes in Men Prescribed Both Drugs for Erectile Dysfunction and Nitrates for Angina.

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Web Exclusive. Annals Consult Guys - Postoperative Bruising: What Is a Clinician to Do?

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Web Exclusive. Annals for Hospitalists Inpatient Notes - Intravenous Iron Supplementation for Patients With Heart Failure-What Hospitalists Should Know.

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Web Exclusive. Annals On Call - Making Sense of E/M Coding Changes.

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Lancet

"Medical crisis" for Rohingya refugees.

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Advancing accurate metrics for future pandemic preparedness.

Pubmed   Journal   ReadQx   PMC

Cautious optimism following weapons talks.

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Digitising the prediction and management of sepsis.

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Doctors renew calls for nuclear disarmament.

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Hope for access to abortion in Kenya.

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Improving diversity in global health governing boards.

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Mwelecele Ntuli Malecela.

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Preventing enterovirus A71 disease: another promising vaccine for children.

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Sam Roberts: Chief Executive of NICE.

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Tranexamic acid for trauma in the USA: is prejudice a barrier to saving lives?

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N Engl J Med

Case 12-2022: A 41-Year-Old Woman with Transient Ischemic Attack and Mitral Valve Masses.

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Congenital Diaphragmatic Hernia in an Adult.

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Crossing Lines - A Change in the Leading Cause of Death among U.S. Children.

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Fighting Cardiac Fibrosis with CAR T Cells.

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Larva Currens in Strongyloides Hyperinfection Syndrome.

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Metric Myopia - Trading Away Our Clinical Judgment.

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Physicians as Political Pawns - The Texas Directive on Gender-Affirming Care and Other Moves.

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Policy Strategies for Addressing Current Threats to the U.S. Nursing Workforce.

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